Ingestible sensors, such as capsule endoscopy and medication monitoring pills, are becoming increasingly popular in the medical domain, yet few studies have considered what experiences may be designed around ingestible sensors. We believe such sensors may create novel bodily experiences for players when it comes to digital games. To understand the potential of ingestible sensors for game designers, we developed a two-player game called the “Guts Game” where the participants play against each other by completing a variety of tasks. Each task requires the players to change their own body temperature measured by an ingestible sensor. From a user study of the Guts Game (N=14), we present four design themes: 1) Designing for Bodily Awareness; 2) Designing for Human-Computer Integration; 2) Designing for Limited Bodily Control; and, 4) Designing for the Cultural Norms. We used the four themes to articulate a set of game design strategies that designers can consider when aiming to develop engaging ingestible games.